Investigations of two potential mechanisms which may favour persistence of CDV, the driving force behind the chronic progression of demyelination in canine distemper
نویسندگان
چکیده
250 Text: 5347 Running Title: Investigation of the expression of a novel putative CDV open reading frame
منابع مشابه
New Aspects of the Pathogenesis of Canine Distemper Leukoencephalitis
Canine distemper virus (CDV) is a member of the genus morbillivirus, which is known to cause a variety of disorders in dogs including demyelinating leukoencephalitis (CDV-DL). In recent years, substantial progress in understanding the pathogenetic mechanisms of CDV-DL has been made. In vivo and in vitro investigations provided new insights into its pathogenesis with special emphasis on axon-mye...
متن کاملMolecular and Immunological Investigation of Canine Distemper Virus (CDV) and Its Co- Infection with Canine Parainfluenza Virus Type 2
Background and Objective: Canine distemper (CD) is a highly transmissible serious disease of carnivores. Distemper virus has immunosuppression effects, which, in turn, could lead to opportunistic infections. The present study was performed to detect CDV by the genomic and immunological methods and investigate its co- infection with canine parainfluenza virus type 2 (CPiV-2). Materials and Meth...
متن کاملDetection of Arctic and European cluster of canine distemper virus in north and center of Iran
Canine distemper virus (CDV) creates a very contagious viral multi-systemic canine distemper (CD) disease that affects most species of Carnivora order. The virus is genetically heterogeneous, particularly in section of the hemagglutinin (H) gene. Sequence analysis of the H gene can be useful to investigate distinction of various lineages related to geographical distribution and CDV molecular ep...
متن کاملAphylogenetic study on the NP gene of detected canine distemper virus in (2008-2011) Iran
BACKGROUND: Canine Distemper (CD) is a lethal systemicdisease affecting a wide variety of terrestrial carnivores.OBJECTIVES: This study was performed to survey epidemiologicaland molecular characteristics of the canine distemper virus(CDV) strains circulating in Iran. METHODS: In this study, 19CDV-suspected unvaccinated dogs from Northeast and center ofIran were analyzed for presence of CDV nuc...
متن کاملDetection and differentiation of wild-type and vaccine strains of canine distemper virus by a duplex reverse transcription polymerase chain reaction
Canine distemper virus (CDV) is the cause of canine distemper (CD) which is a severe and highly contagious disease in dogs. In the present study, a duplex reverse transcription polymerase chain reaction (RT-PCR) method was developed for the detection and differentiation of wild-type and vaccine strains of CDV. Four primers were designed to detect and discriminate the two viruses by generating 6...
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تاریخ انتشار 2010